Evolving desired functionalities for integrated PHRs including studies that solicit future functionalities from the perspectives of patients, special populations, payers, providers, regulators, patient advocacy groups, etc. Development and refinement of integrated PHR models for health communications and care, and identification of the applications and devices that hold the greatest transformative potential. Impact studies on the effectiveness of PHRs through a systematic review of business cases and clinical use cases, and on the impact of PHRs on individual health and their potential for proactive prevention and disease prediction.▪ Evaluation of models of care delivery that are integrated with PHRs and PHR systems.▪ Liability issues and other legal barriers that confront PHR implementers.▪ Implications of integrated PHRs' use of multisource, heterogeneous and context-aware information for privacy protection, security and semantic interoperability.▪ Use of informed consent with the integrated PHR as a process for individuals to authorize the exchange of personal health information for various purposes (e.g., health data reuse for public health, research purposes).Needs of special populations including rural, minority, central city poor, physically handicapped, and non-English speaking persons.In the short term there is a need to obtain additional sound, objective, and credible information about consumers' views of the value of integrated PHRs and desired PHR functionalities . For example, Project HealthDesign (PHD), the Robert Wood Johnson (RWJ) initiative to support creation of a new generation of personal health record (PHR) systems, released an advanced draft of a set of functional requirements which the program believes will be common to most PHR applications. This information is particularly needed since technological and societal forces are shifting.